In order to evaluate the clinical usefulness of glycosylated ho:noglobin in diabetics, authors measured glycosylated hemoglobin and blood sugar level in 25 normal persons and 25 diabetic patients before and after diabetic treatment.
The glycosylated hemoglobin level in diabetics was significantly higher than that of normal control (9.4±1.69% vs. 4.5±0.63%).
After control of blood sagar in diabetics, the glycosylated hemoglobin level was significantly decreased compared with that of untreated diabetics, from 9.4±1.69% to 7.7±1.10%, p<0.005) but in 16% of cases, the glycosylated hemoglobin level was increased after treatment.
Correlation between glycosylated hemoglobin and blood sugar level was significant as a whole(r= 0.606, p<0.001), but not significant in before or after diabetic control separately.
The glycosylated hemoglobin level of diabetics whose duration of illness was longer than 5 years was slightly higher than that of diabetics whose duration of illness was shorter than 5 years.
The glycosylated hemoglobin level in diabetics with retinopathy was lower than that of diabetics without retinopathy.
These results suggest that HbA, measured by ordinary chromatographic or electrophoretic method does not seems to be an accurate indicator of long-term blood sugar control.
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